PAFAH1B3抗体—艾普蒂

The PAFAH1B3 antibody is designed to detect PAFAH1B3 (Platelet-Activating Factor Acetylhydrolase 1B3), a subunit of the intracellular type I PAF-AH enzyme complex. This enzyme hydrolyzes platelet-activating factor (PAF) and related phospholipids, regulating inflammatory responses and lipid metabolism. PAFAH1B3. encoded by the PAFAH1B3 gene on chromosome 19. forms heterotrimers with PAFAH1B2 and the catalytic alpha subunit PAFAH1B1 (also known as LIS1). While PAFAH1B1 is linked to neuronal migration and lissencephaly, PAFAH1B3's role extends beyond neural development. Recent studies highlight its overexpression in cancers, including ovarian, breast, and hepatocellular carcinoma, where it promotes tumor growth, metastasis, and chemoresistance by modulating lipid signaling and metabolic pathways. The PAFAH1B3 antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular localization, and pathological relevance. Its applications span cancer research, neurobiology, and inflammation studies, offering insights into disease mechanisms and potential therapeutic targets. Researchers also explore PAFAH1B3 as a biomarker for prognosis and treatment response in oncology. Commercial antibodies are typically validated for specificity against recombinant human PAFAH1B3. ensuring reliability in experimental models.