RAB39A抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P10313(RAB39A Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10313(RAB39A Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

**Background of RAB39A Antibody**

RAB39A is a member of the RAB family of small GTPases, which regulate intracellular vesicle trafficking, membrane dynamics, and organelle organization. Specifically, RAB39A is implicated in secretory pathways, autophagy, and endosomal-lysosomal systems. Unlike its paralog RAB39B, which is linked to X-linked intellectual disability and Parkinson’s disease, RAB39A’s functional roles remain less characterized but are thought to involve neurodevelopment, immune regulation, and cellular homeostasis.

Antibodies targeting RAB39A are essential tools for studying its expression, localization, and interactions. These antibodies enable researchers to detect RAB39A in various experimental setups, such as Western blotting, immunofluorescence, and immunohistochemistry. They are often validated using knockout cell lines or tissues to ensure specificity, given the high homology among RAB proteins.

Research using RAB39A antibodies has uncovered its potential involvement in diseases, including cancer and neurodegenerative disorders. For instance, altered RAB39A expression has been observed in gliomas and immune-related conditions, suggesting roles in tumor progression or inflammation. However, challenges persist, such as limited commercial availability of high-affinity antibodies and incomplete understanding of RAB39A’s signaling networks.

Overall, RAB39A antibodies are critical for elucidating the protein’s biological significance and therapeutic potential, bridging gaps in cellular trafficking mechanisms and disease pathology.