PRELID3B抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10288(PRELID3B Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10288(PRELID3B Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

The PRELID3B (PRELI Domain-Containing Protein 3B) antibody is a tool used to detect and study the PRELID3B protein, a member of the PRELI family involved in mitochondrial function. PRELID3B is localized to mitochondria and plays a role in maintaining mitochondrial membrane integrity, lipid transport, and apoptosis regulation. It interacts with other mitochondrial proteins, such as TRIAP1. to modulate cardiolipin synthesis, a lipid critical for mitochondrial dynamics and cellular energy metabolism. Dysregulation of PRELID3B has been linked to mitochondrial disorders, cancer, and neurodegenerative diseases, making it a focus of pathophysiological research.

The PRELID3B antibody enables researchers to investigate the protein's expression, localization, and interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is particularly valuable in studies exploring mitochondrial dysfunction, metabolic reprogramming in cancer, or cell death pathways. Commercial PRELID3B antibodies are typically produced in hosts like rabbits or mice, validated for specificity using knockout controls or siRNA silencing. Research utilizing this antibody has highlighted PRELID3B's role in balancing mitochondrial homeostasis, influencing cellular responses to stress, and its potential as a therapeutic target. Ongoing studies aim to clarify its mechanisms in disease contexts, emphasizing its importance in mitochondrial biology and pathology.