PAM16抗体—艾普蒂

The PAM16 (Presence Activated Mitochondrial 16 kDa) antibody targets a conserved mitochondrial inner membrane protein critical for cellular energy metabolism. PAM16. also known as TIM16. is a key component of the TIM23 (Translocase of the Inner Mitochondrial Membrane) complex, which facilitates the import and sorting of nuclear-encoded precursor proteins into the mitochondrial matrix. It interacts with PAM18 (TIM14) to regulate the ATP-dependent protein translocation machinery, maintaining mitochondrial membrane potential and ensuring proper folding/assembly of imported proteins. Dysregulation of PAM16 is linked to mitochondrial dysfunction, impacting ATP production, oxidative stress response, and apoptosis. Studies associate altered PAM16 expression with neurodegenerative diseases, metabolic disorders, and cancer. The PAM16 antibody is widely used in research to investigate mitochondrial protein import mechanisms, assess mitochondrial health in disease models, and validate PAM16 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its role in cellular homeostasis makes it a biomarker of interest for exploring therapeutic strategies targeting mitochondrial pathways.