PHPT1抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P10235(PHPT1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10235(PHPT1 Antibody) at dilution 1/210. (Original magnification: ×200)    

  
  

The PHPT1 (Phosphohistidine Phosphatase 1) antibody is a tool used to study the enzyme PHPT1. which plays a critical role in regulating protein histidine phosphorylation—a less common but biologically significant post-translational modification. PHPT1 specifically catalyzes the dephosphorylation of phosphohistidine residues, modulating signaling pathways involved in cellular processes such as metabolism, proliferation, and stress responses. Unlike serine/threonine or tyrosine phosphorylation, histidine phosphorylation is transient and challenging to detect, making PHPT1 a key focus in understanding its regulatory mechanisms.

PHPT1 antibodies are essential for detecting and quantifying PHPT1 expression in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help researchers investigate PHPT1's tissue distribution, subcellular localization, and interaction partners. Studies have linked PHPT1 to metabolic regulation, with evidence suggesting its involvement in insulin signaling and mitochondrial function. Dysregulation of PHPT1 has been implicated in metabolic disorders and cancer, highlighting its potential as a therapeutic target.

The development of specific PHPT1 antibodies addresses challenges in studying histidine phosphorylation dynamics, offering insights into its underappreciated role in cellular signaling. Ongoing research aims to clarify PHPT1's molecular mechanisms and its broader implications in health and disease.