GABARAPL2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10230(GABARAPL2 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

**Background of GABARAPL2 Antibody**

GABARAPL2 (Gamma-aminobutyric acid receptor-associated protein-like 2), also known as GATE-16. is a member of the GABARAP family involved in intracellular membrane trafficking, autophagy, and protein degradation. It plays a critical role in autophagosome formation, lysosomal fusion, and cargo recognition during autophagy, a cellular process essential for maintaining homeostasis and responding to stress. GABARAPL2 interacts with microtubule-associated proteins, ubiquitinated substrates, and components of the autophagy machinery (e.g., LC3. ATG5-ATG12), facilitating targeted degradation of cellular components.

Antibodies targeting GABARAPL2 are vital tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate autophagy dynamics, particularly in cancer, neurodegenerative diseases, and metabolic disorders. Dysregulation of GABARAPL2 has been linked to autophagy-related pathologies, making its detection crucial for understanding disease mechanisms. These antibodies often exhibit specificity for conserved epitopes across species, enabling cross-species research. Validated antibodies help dissect GABARAPL2's roles beyond autophagy, including its involvement in immune responses and membrane repair, underscoring its multifaceted cellular impact.