AP1S3抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10223(AP1S3 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10223(AP1S3 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The AP1S3 antibody targets the Adaptor Protein Complex 1 Sigma 3 subunit (AP1S3), a key component of the AP-1 complex involved in intracellular protein trafficking and membrane sorting. AP-1 facilitates vesicle formation between the trans-Golgi network, endosomes, and lysosomes, playing a critical role in maintaining cellular homeostasis. AP1S3 specifically regulates epidermal differentiation and skin barrier function through interactions with pathways like Notch and autophagy. Mutations in the AP1S3 gene are linked to inflammatory skin disorders, notably pustular psoriasis (e.g., generalized pustular psoriasis or palmoplantar pustulosis) and occasionally atopic dermatitis. These mutations disrupt keratinocyte differentiation, lysosomal dysfunction, and immune dysregulation, driving disease pathology.

AP1S3 antibodies are essential tools for studying its expression, localization, and interactions in disease models. They enable detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, helping to elucidate AP1S3's role in skin inflammation and autophagy. Clinically, AP1S3 antibodies may aid in diagnosing genetic subtypes of pustular psoriasis or monitoring therapeutic responses. Research also explores their potential in targeting AP1S3-related pathways for novel treatments. Overall, AP1S3 antibodies bridge mechanistic insights into skin biology and translational applications in dermatology.