RNF13抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10134(RNF13 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10134(RNF13 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The RNF13 antibody is a research tool designed to detect and study the Ring Finger Protein 13 (RNF13), a member of the RING finger family of E3 ubiquitin ligases. RNF13 is characterized by a conserved RING domain that facilitates interactions with E2 ubiquitin-conjugating enzymes, enabling substrate ubiquitination—a critical process in protein degradation, trafficking, and signaling. This transmembrane protein is broadly expressed in tissues, including the brain, heart, and immune cells, and is implicated in regulating apoptosis, endoplasmic reticulum-associated degradation (ERAD), and neurodevelopment. Dysregulation of RNF13 has been linked to neurodegenerative disorders (e.g., Alzheimer’s disease), cancer progression, and immune responses, highlighting its potential as a therapeutic or diagnostic target.

RNF13 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable the detection of RNF13 via techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of its expression patterns, subcellular localization (e.g., Golgi apparatus, endosomes), and interactions with binding partners. Validation of these antibodies includes testing for specificity, sensitivity, and cross-reactivity, with some variants recognizing distinct isoforms or post-translational modifications. Recent studies utilizing RNF13 antibodies have uncovered its role in modulating stress responses and neuronal survival, underscoring its relevance in cellular homeostasis and disease mechanisms. These tools remain vital for deciphering RNF13's complex biological functions.