LDB1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10130(LDB1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10130(LDB1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The LDB1 antibody is a research tool used to study the LIM-domain binding protein 1 (LDB1), a crucial adaptor protein involved in transcriptional regulation. LDB1 lacks DNA-binding activity but facilitates the assembly of multi-protein complexes by interacting with LIM-domain-containing transcription factors, such as LMO, LHX, and ISL families. These complexes play vital roles in embryonic development, cell differentiation, and tissue-specific gene expression. LDB1 is essential for normal hematopoiesis, neurogenesis, and organogenesis, and its dysregulation has been linked to cancers, including T-cell leukemia and solid tumors.

Antibodies targeting LDB1 enable the detection and analysis of its expression, localization, and interactions in various experimental settings, such as Western blotting, immunoprecipitation, and immunofluorescence. They are particularly valuable in studying developmental pathways (e.g., Wnt/β-catenin signaling) and oncogenic mechanisms. Validated LDB1 antibodies are critical for confirming protein knockdown/knockout efficiency and mapping binding partners in chromatin-remodeling complexes. Commercial LDB1 antibodies are typically raised against specific epitopes (e.g., human LDB1 N-terminal or C-terminal regions) and validated for cross-reactivity in model organisms like mice and zebrafish. Their applications span basic research in developmental biology, cancer studies, and drug discovery pipelines targeting transcriptional co-regulators.