MKX抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10114(MKX Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10114(MKX Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The MKX antibody is a crucial tool in biomedical research, specifically targeting the Mohawk Homeobox (MKX) transcription factor. MKX, a member of the three-amino-acid loop extension (TALE) homeodomain protein family, plays a pivotal role in regulating tissue development, particularly in tendons, muscles, and cartilage. Discovered in 2010. MKX is essential for tendon differentiation and maintenance by modulating extracellular matrix synthesis and cell proliferation. Its dysfunction is linked to musculoskeletal disorders, including tendon pathologies and osteoarthritis.

Researchers employ MKX antibodies to detect and quantify MKX protein expression in various experimental models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study MKX's spatial-temporal expression during embryogenesis and tissue repair. Commercial MKX antibodies are typically raised in rabbits or mice, with validation in knockout controls to ensure specificity.

Recent studies highlight MKX's role beyond tendon biology, including its involvement in chondrogenesis and muscle fiber organization. MKX antibodies have also facilitated investigations into regenerative medicine, particularly in stem cell differentiation toward tendon-like lineages. Additionally, they aid in exploring MKX's interactions with signaling pathways like TGF-β and BMP, offering insights into therapeutic targets for connective tissue diseases. Proper validation remains critical due to potential cross-reactivity with other homeodomain proteins.