TEAD3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10095(TEAD3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10095(TEAD3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The TEAD3 antibody is a research tool used to detect and study the TEAD3 protein, a member of the Transcriptional Enhanced Associate Domain (TEAD) family of transcription factors. TEAD proteins (TEAD1-4) regulate gene expression by binding to DNA through a conserved TEA/ATTS domain and interacting with coactivators like YAP (Yes-associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) in the Hippo signaling pathway. TEAD3. encoded by the *TEAD3* gene, plays critical roles in embryonic development, cell proliferation, and organ growth. It exhibits tissue-specific expression, with higher activity in placental and certain cancer cells.

Research using TEAD3 antibodies has highlighted its involvement in tumorigenesis, particularly in cancers such as ovarian and hepatocellular carcinoma, where TEAD3 overexpression correlates with poor prognosis. These antibodies are essential for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize TEAD3 localization and quantify its expression in cellular or tissue samples. Specificity validation is crucial, as TEAD family members share structural homology. Recent studies also explore TEAD3's role in Hippo pathway dysregulation and its potential as a therapeutic target. Commercial TEAD3 antibodies are typically developed in hosts like rabbits or mice, targeting unique epitopes to ensure specificity.