TRAPPC1抗体—艾普蒂

The TRAPPC1 (Trafficking Protein Particle Complex subunit 1) antibody is a tool used to study the TRAPP (TRAnsport Protein Particle) complex, a conserved multi-subunit assembly critical for intracellular membrane trafficking. TRAPPC1. a core component of the TRAPP I complex, facilitates vesicle-mediated transport between the endoplasmic reticulum and Golgi apparatus by acting as a guanine nucleotide exchange factor (GEF) for Rab GTPases like Rab1. Dysregulation of TRAPPC1 is linked to neurodevelopmental disorders, cancer, and ciliopathies, underscoring its role in cellular homeostasis. Researchers use TRAPPC1 antibodies in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions. These studies aim to elucidate mechanisms underlying diseases like autosomal recessive mental retardation 35 (MRT35) and medulloblastoma. Commercially available TRAPPC1 antibodies are typically raised in rabbits or mice against specific epitopes, validated for specificity via knockout controls. Recent studies also explore its involvement in autophagy and cell cycle regulation. As a biomarker, TRAPPC1 expression levels may correlate with disease progression, making its antibody valuable for diagnostic and therapeutic research.