NTAN1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10087(NTAN1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10087(NTAN1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of NTAN1 Antibody**

NTAN1 (N-terminal asparagine amidase) is a conserved enzyme involved in the N-end rule pathway, a ubiquitin-mediated proteolytic system that regulates protein degradation based on N-terminal residues. It specifically catalyzes the deamidation of N-terminal asparagine (N) to aspartate (D), enabling subsequent arginylation and ubiquitination of substrate proteins by downstream components of the pathway. This process impacts protein stability, turnover, and cellular homeostasis.

NTAN1 antibodies are tools used to study the expression, localization, and functional roles of NTAN1 in biological systems. Research has linked NTAN1 to critical processes such as apoptosis, DNA repair, and development. For instance, studies in *Ntan1*-deficient mice reveal metabolic abnormalities, reduced lifespan, and impaired stress responses, highlighting its physiological significance. Dysregulation of NTAN1 has also been implicated in pathologies, including cancer and neurodegenerative disorders, where altered protein degradation pathways contribute to disease progression.

Antibodies targeting NTAN1 enable detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in mechanistic studies of the N-end rule pathway. They are essential for exploring NTAN1's interactions with substrates (e.g., caspase-cleaved proteins) or binding partners (e.g., UBR family E3 ubiquitin ligases). As interest in proteostasis grows, NTAN1 antibodies remain valuable for dissecting its role in health and disease.