HMBOX1抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07206(CLEC2B Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The HMBOX1 (Homeobox containing 1) antibody targets a protein encoded by the HMBOX1 gene, which belongs to the homeobox family of genes. These genes are characterized by a conserved DNA-binding homeodomain and play critical roles in developmental regulation and cellular differentiation. HMBOX1. also known as PBXIP1 or HPIP, is a nuclear protein implicated in diverse biological processes, including telomere maintenance, cell proliferation, apoptosis, and transcriptional regulation. Emerging studies suggest its involvement in cancer progression (e.g., liver, gastric, and breast cancers), immune modulation, and stem cell properties, though its precise mechanisms remain under investigation.

HMBOX1 antibodies are primarily used in research to detect and quantify HMBOX1 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically produced in immunized hosts (e.g., rabbits or mice) using recombinant HMBOX1 protein fragments or synthetic peptides as antigens. Validation includes specificity checks through knockdown/knockout controls and cross-reactivity assessments.

The interest in HMBOX1 stems from its potential as a biomarker or therapeutic target. Dysregulated HMBOX1 expression has been linked to tumorigenesis, chemoresistance, and immune evasion. For instance, HMBOX1 may interact with telomerase or modulate Wnt/β-catenin signaling, influencing cancer cell survival. Researchers rely on HMBOX1 antibodies to explore these pathways, aiming to uncover novel diagnostic or treatment strategies for HMBOX1-associated diseases.