UNKL抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10079(UNKL Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10079(UNKL Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

UNKL (Unkeller family member) is a poorly characterized protein encoded by the *UNKL* gene, part of the Unkeller family implicated in diverse cellular processes, including transcriptional regulation, RNA processing, and cell differentiation. Structurally, UNKL contains conserved domains such as zinc fingers and leucine-rich repeats, suggesting roles in protein-protein or protein-nucleic acid interactions. While its exact molecular functions remain unclear, studies link UNKL to developmental pathways, immune regulation, and cancer. For instance, UNKL may interact with the Notch signaling pathway, influencing cell fate decisions, and has been associated with hematopoietic stem cell differentiation.

Anti-UNKL antibodies, detected in autoimmune diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are considered rare autoantibodies. Their clinical significance remains under investigation, though their presence in patient sera suggests potential roles as disease biomarkers. Mechanistically, UNKL autoantibodies might arise from molecular mimicry or dysregulated immune tolerance, targeting epitopes critical for UNKL’s function. However, the pathogenicity of these antibodies and their contribution to disease progression are not fully established. Current research focuses on elucidating UNKL’s physiological roles, its antigenic properties in autoimmunity, and its potential as a therapeutic target. Further studies are needed to clarify its involvement in immune dysregulation and its diagnostic or prognostic utility in autoimmune disorders.