ZNF688抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 and 231 cell lysates, Primary antibody: P10078(ZNF688 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10078(ZNF688 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10078(ZNF688 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

The ZNF688 antibody is a tool used to study the ZNF688 protein, a member of the zinc finger protein family characterized by C2H2-type zinc finger domains, which facilitate DNA or RNA binding. ZNF688 is implicated in transcriptional regulation and chromatin remodeling, though its exact biological roles remain less characterized compared to other zinc finger proteins. It is ubiquitously expressed, with higher levels observed in tissues like the liver, kidney, and immune cells. Research suggests potential involvement in cancer pathways, particularly through interactions with tumor suppressors or oncogenic complexes, though mechanistic insights are limited.

ZNF688 antibodies are typically developed in hosts such as rabbits or mice, targeting specific epitopes within its N-terminal or zinc finger regions. These antibodies are essential for applications like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to map DNA-binding sites or protein interactions. Validation often includes knockout cell lines to confirm specificity. Despite its emerging relevance, ZNF688's functional diversity and regulatory networks require further exploration. Current studies focus on its role in cellular stress responses, differentiation, and possible contributions to malignancies like hepatocellular carcinoma or leukemia, highlighting its potential as a biomarker or therapeutic target.