MAMDC2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10065(MAMDC2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The MAMDC2 (MAM domain-containing protein 2) antibody is a tool used to detect the MAMDC2 protein, which belongs to the MAM (Meprin/A5 protein/PTPmu) domain-containing family. This conserved domain is implicated in cell adhesion, receptor signaling, and extracellular interactions. MAMDC2. also known as MDGA2. is a transmembrane or secreted glycoprotein involved in regulating cell-cell communication, neuronal development, and synaptic organization. Studies suggest its potential role in modulating the Slit-Robo signaling pathway, which influences axon guidance and neural circuit formation.

The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables researchers to study MAMDC2's expression patterns, localization, and function in tissues, particularly in the nervous system. Applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often involves knockout controls or siRNA-mediated silencing to confirm specificity.

While MAMDC2's biological significance remains under investigation, its dysregulation has been tentatively linked to neurodevelopmental disorders and cancer metastasis. The antibody thus serves as a critical reagent for exploring MAMDC2's mechanistic roles in health and disease. Recent studies also highlight its interaction with extracellular matrix components, suggesting involvement in tissue remodeling processes.