SCNM1抗体—艾普蒂

The SCNM1 (sodium channel modifier 1) antibody is a tool used to study the SCNM1 protein, which plays a role in RNA splicing by modulating the activity of the survival motor neuron (SMN) complex. SCNM1 contains a conserved N-terminal coiled-coil domain and interacts with components of the SMN complex, contributing to the assembly of small nuclear ribonucleoproteins (snRNPs), essential for spliceosome function. Dysregulation of SCNM1 has been implicated in spinal muscular atrophy (SMA) and other neuromuscular disorders linked to defective RNA splicing. The SCNM1 antibody is primarily employed in research to detect and quantify SCNM1 expression in tissues or cells via techniques like Western blotting, immunofluorescence, or immunohistochemistry. It aids in elucidating SCNM1's localization, protein-protein interactions, and its role in splicing mechanisms. Studies using this antibody have helped clarify how SCNM1 deficiency impacts snRNP assembly and contributes to splicing defects observed in SMA models. Commercial SCNM1 antibodies are typically raised in rabbits or mice, validated for specificity, and used in both basic and translational research to explore therapeutic strategies targeting splicing pathways.