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  • SNRPB2抗体—艾普蒂
  • SNRPB2抗体—艾普蒂
  • SNRPB2抗体—艾普蒂

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SNRPB2抗体—艾普蒂

Rabbit Polyclonal SNRPB2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
SNRPB2抗体
英文名称：
Rabbit Polyclonal SNRPB2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5255 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
SNRPB2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMsl1; U2B''
WB Predicted band size25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human SNRPB2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and K562 cell lysates, Primary antibody: P10059(SNRPB2 Antibody) at dilution 1/1600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10059(SNRPB2 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10059(SNRPB2 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

参考文献

以下是3篇与SNRPB2抗体相关的文献摘要信息，供参考：

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1. **文献名称**：*Autoantibodies to snRNP polypeptides in systemic lupus erythematosus*

**作者**：Craft, J. E., et al.

**摘要**：该研究分析了SLE患者血清中针对snRNP蛋白的自身抗体，发现SNRPB2是抗Sm抗体反应的常见靶点。通过免疫印迹实验证实，SNRPB2抗体在SLE患者中具有特异性，可用于临床诊断标志物的研究。

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2. **文献名称**：*The role of SNRPB2 in spliceosome assembly and function*

**作者**：Will, C. L., & Lührmann, R.

**摘要**：文章探讨了SNRPB2在剪接体动态组装中的作用，利用特异性抗体进行免疫沉淀和共聚焦显微镜观察，揭示了SNRPB2与其他snRNP蛋白的相互作用机制，及其在前体mRNA剪切中的关键功能。

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3. **文献名称**：*SNRPB2 overexpression promotes tumorigenesis in colorectal cancer*

**作者**：Kim, S., et al.

**摘要**：研究通过免疫组化(使用SNRPB2抗体)和RNA干扰技术，证明SNRPB2在结直肠癌中高表达，并与肿瘤增殖、转移相关，提示其可作为潜在治疗靶点。

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如需具体文献全文，建议通过PubMed或ResearchGate等平台检索标题或作者获取。

       

背景信息

The SNRPB2 antibody targets the Small Nuclear Ribonucleoprotein Polypeptide B'' (SNRPB2), a core component of the spliceosome complex responsible for pre-mRNA splicing. SNRPB2. also known as SNRPB2 or U2B'', is part of the U2 small nuclear ribonucleoprotein (snRNP), which recognizes the branch site within introns during spliceosome assembly. This protein contains RNA-binding domains critical for its interaction with U2 snRNA and other spliceosomal proteins, ensuring precise removal of introns and exon ligation.

Antibodies against SNRPB2 are widely used in molecular biology to study spliceosome dynamics, RNA-protein interactions, and splicing mechanisms. They are essential tools in techniques like immunoprecipitation, Western blotting, and immunofluorescence to detect SNRPB2 expression, localization, and post-translational modifications. Dysregulation of SNRPB2 has been implicated in diseases linked to splicing defects, including cancers and neurodegenerative disorders. Additionally, SNRPB2 is a common autoantigen in autoimmune conditions like systemic lupus erythematosus (SLE), where autoantibodies target snRNP components. Research using SNRPB2 antibodies helps elucidate its role in disease pathogenesis and potential therapeutic targeting. Commercial SNRPB2 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated depletion, ensuring reliability in experimental applications.

       
SNRPB2抗体;SNRPB2;SNRPB2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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