DCAF10抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10057(DCAF10 Antibody) at dilution 1/130. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10057(DCAF10 Antibody) at dilution 1/130. (Original magnification: ×200)    

  
  

The DCAF10 (DDB1- and CUL4-associated factor 10) antibody is a research tool used to study the DCAF10 protein, a member of the WD40 repeat-containing DCAF family. DCAF10 serves as a substrate receptor within the CUL4-DDB1 E3 ubiquitin ligase complex (CRL4), which plays a critical role in ubiquitination-mediated protein degradation. This protein is involved in recruiting specific substrates for polyubiquitination, marking them for proteasomal destruction. DCAF10's interactions are linked to cellular processes such as DNA repair, cell cycle regulation, and epigenetic modulation, though its exact biological functions remain under investigation.

Antibodies targeting DCAF10 enable researchers to detect, quantify, or localize the protein in various experimental models (e.g., Western blot, immunofluorescence, IP). They are essential for exploring DCAF10's role in diseases, particularly cancer, where dysregulation of ubiquitin-proteasome pathways is common. Recent studies suggest DCAF10 may influence oncogenic signaling or drug resistance, making it a potential therapeutic target. However, detailed mechanistic insights and clinical relevance require further validation. Commercial DCAF10 antibodies are typically validated for specificity and affinity, though performance may vary across applications. Ongoing research aims to clarify its interactome and regulatory networks in cellular homeostasis and pathology.