HS1BP3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 and NIH/3T3 cell lysates, Primary antibody: P10051(HS1BP3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10051(HS1BP3 Antibody) at dilution 1/140. (Original magnification: ×200)    

  
  

The HS1BP3 (HCLS1-binding protein 3) antibody is a tool used to study the HS1BP3 protein, a regulator of cellular processes linked to hematopoiesis, immune response, and cancer. HS1BP3 interacts with HCLS1 (Hematopoietic lineage cell-specific protein 1), a cytoskeletal protein involved in lymphocyte activation and signaling. Structurally, HS1BP3 contains a proline-rich domain and a nuclear localization signal, suggesting roles in protein-protein interactions and nuclear transport. Studies indicate its involvement in modulating cell migration, proliferation, and apoptosis, particularly in hematopoietic and immune cells.

HS1BP3 is implicated in pathological contexts, including cancers like hepatocellular carcinoma and leukemia, where its dysregulation correlates with tumor progression. It also interacts with viral proteins, potentially influencing viral replication and immune evasion. The antibody against HS1BP3 (often rabbit or mouse-derived, monoclonal/polyclonal) is utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect expression levels, subcellular localization, and interaction partners. Research employing this antibody aims to elucidate HS1BP3's mechanistic roles in signaling pathways (e.g., B-cell receptor signaling) and its potential as a therapeutic target or biomarker. Commercial availability and specificity validation make it critical for studies exploring immune dysfunction, oncogenesis, and host-pathogen interactions.