ASB6抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10040(ASB6 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ASB6 antibody is a research tool targeting the Ankyrin Repeat and SOCS Box (ASB) family member 6 protein, encoded by the ASB6 gene in humans. ASB proteins are characterized by their conserved N-terminal ankyrin repeat domains, which mediate protein-protein interactions, and C-terminal SOCS boxes that recruit E3 ubiquitin ligase complexes. ASB6 is implicated in ubiquitination-mediated protein degradation, a critical process for cellular homeostasis, signaling, and disease regulation. While its specific biological roles remain under investigation, ASB6 is thought to interact with Cullin5 to form an E3 ligase complex, potentially regulating substrates involved in metabolic or signaling pathways.

ASB6 antibodies are primarily used in experimental settings like Western blotting, immunofluorescence, and immunohistochemistry to detect ASB6 expression levels, localization, and interactions in various tissues or cell lines. Research has explored its expression patterns in cancers and neurological disorders, though findings are still preliminary. Commercial ASB6 antibodies are typically developed in rabbits or mice using immunogenic peptides derived from human ASB6 sequences. Challenges include ensuring antibody specificity due to structural similarities among ASB family members. Current studies aim to clarify ASB6's physiological substrates and its relevance to diseases linked to dysregulated ubiquitination, such as neurodegeneration or tumorigenesis.