ZNF581抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10039(ZNF581 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of ZNF581 Antibody**

ZNF581 (Zinc Finger Protein 581) is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which plays roles in transcriptional regulation and epigenetic modulation. It functions as a transcriptional repressor, potentially interacting with DNA methyltransferases (DNMTs) to regulate gene expression through promoter methylation. Studies suggest ZNF581 is implicated in cancer biology, where its expression is often downregulated in malignancies such as colorectal cancer, leukemia, and breast cancer. This downregulation may promote tumor progression by enhancing cell proliferation, invasion, or resistance to apoptosis, possibly via epigenetic silencing of tumor suppressor genes or dysregulation of pathways like Wnt or TGF-β.

The ZNF581 antibody is a critical tool for detecting and quantifying ZNF581 protein levels in research. Typically developed in hosts like rabbits or mice, it is widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study ZNF581's expression patterns, subcellular localization, and interactions in cellular or tissue samples. Researchers employ this antibody to explore ZNF581's roles in cancer development, cellular differentiation, and epigenetic regulation, as well as its potential as a diagnostic biomarker or therapeutic target. Validation of the antibody includes specificity checks via knockout controls or peptide blocking assays to ensure reliability in experimental models.

Overall, the ZNF581 antibody serves as a vital reagent for dissecting the molecular mechanisms of ZNF581 in health and disease, particularly in oncology and epigenetics research.