SCAND1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10027(SCAND1 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

The SCAND1 (SCAN domain-containing protein 1) antibody is a tool used to study the SCAND1 protein, which belongs to the SCAN domain family. This domain, found in zinc finger-containing proteins, mediates protein-protein interactions, particularly in transcriptional regulation. SCAND1 lacks intrinsic DNA-binding capacity but acts as a transcriptional regulator by interacting with other SCAN domain proteins, such as certain zinc finger transcription factors, to modulate their activity. It may function as a co-repressor or competitive inhibitor, influencing the formation of transcriptional complexes.

SCAND1 is implicated in cellular processes like proliferation, differentiation, and apoptosis. Studies suggest its role in cancer biology, with altered expression observed in prostate, breast, and other cancers, though its exact function (tumor suppressor or oncogene) remains context-dependent. It also interacts with chromatin modifiers, linking it to epigenetic regulation.

The SCAND1 antibody enables detection and localization of SCAND1 in cells and tissues through techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is critical for investigating SCAND1's molecular mechanisms, protein interactions, and disease associations. Researchers use it to explore SCAND1's involvement in transcriptional networks and its potential as a therapeutic target. Specificity validation via knockout controls is essential due to cross-reactivity risks with other SCAN domain proteins.