GSG1L抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10023(GSG1L Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10023(GSG1L Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The GSG1L (Germ Cell-Specific Gene 1-Like) protein, encoded by the GSG1L gene, is a relatively understudied transmembrane protein belonging to the tetraspanin family. It is predominantly expressed in the brain, particularly in neurons, and has been implicated in regulating synaptic transmission and plasticity. GSG1L interacts with AMPA-type glutamate receptors (AMPARs), key mediators of excitatory signaling, and modulates their trafficking and functional properties. Studies suggest it acts as an auxiliary subunit, influencing receptor kinetics and synaptic strength.

GSG1L antibodies are critical tools for investigating its expression, localization, and molecular interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Research using these antibodies has revealed GSG1L's enrichment at postsynaptic densities and its role in fine-tuning synaptic efficacy, potentially impacting learning and memory processes. Dysregulation of GSG1L has been tentatively linked to neurological disorders, including epilepsy and autism spectrum disorders, though mechanistic insights remain limited.

Despite progress, GSG1L's precise physiological and pathological roles require further exploration. Antibody specificity remains a challenge due to protein homology within the tetraspanin family. Ongoing studies aim to clarify its interaction networks and therapeutic relevance, positioning GSG1L as an emerging player in synaptic biology and neuropathology.