NIPBL抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10022(NIPBL Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

**Background of NIPBL Antibody**

The NIPBL antibody targets the Nipped-B-like (NIPBL) protein, a critical regulatory factor involved in chromosomal architecture and cohesion. NIPBL, encoded by the *NIPBL* gene located on chromosome 5p13.2. serves as a loading factor for the cohesin complex—a multi-subunit protein assembly essential for sister chromatid cohesion, DNA repair, and transcriptional regulation. By facilitating cohesin’s loading onto chromatin, NIPBL ensures proper chromosome segregation during cell division and modulates three-dimensional genome organization, influencing gene expression patterns.

Mutations in *NIPBL* are the primary cause of Cornelia de Lange syndrome (CdLS), a rare developmental disorder characterized by craniofacial abnormalities, growth retardation, and intellectual disability. The NIPBL antibody is widely utilized in research to study protein expression, localization, and functional interactions in both normal and diseased states. It aids in diagnosing CdLS through Western blotting, immunofluorescence, or immunohistochemistry, helping correlate genetic variants with clinical phenotypes. Additionally, this antibody is instrumental in exploring cohesinopathies and cancer biology, as cohesin dysfunction is implicated in tumorigenesis. Challenges remain in standardizing detection methods and interpreting low-abundance NIPBL signals in certain tissues. Ongoing studies aim to refine its applications in mechanistic and therapeutic research.