ZNF580抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10020(ZNF580 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ZNF580 antibody is a research tool designed to detect and study the zinc finger protein 580 (ZNF580), a transcription factor belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF580 is implicated in regulating gene expression, particularly in processes like cell proliferation, differentiation, and apoptosis. It has been studied in the context of cardiovascular biology, where it may influence endothelial cell function and angiogenesis, as well as in cancer research, where its dysregulation has been linked to tumor progression or suppression, depending on the cellular context.

The antibody is commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to localize and quantify ZNF580 expression in tissues or cultured cells. Its development stems from the need to explore ZNF580's role in diseases like atherosclerosis, hypertension, and certain cancers, where altered expression levels have been observed. Researchers also utilize it to investigate signaling pathways involving ZNF580. such as interactions with TGF-β or MAPK cascades. Validation typically includes testing for specificity via knockout controls or siRNA silencing. Commercial availability from multiple biotech vendors has facilitated its adoption in basic and translational studies aiming to clarify ZNF580's functional mechanisms and therapeutic potential.