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  • NHP2抗体—艾普蒂
  • NHP2抗体—艾普蒂
  • NHP2抗体—艾普蒂

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NHP2抗体—艾普蒂

Rabbit Polyclonal NHP2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
NHP2抗体
英文名称：
Rabbit Polyclonal NHP2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5216 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
NHP2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDKCB2; NHP2P; NOLA2
WB Predicted band size17 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human NHP2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human spleen tissue lysate, Primary antibody: P10008(NHP2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10008(NHP2 Antibody) at dilution 1/55. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10008(NHP2 Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是关于NHP2抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需根据真实文献调整)：

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1. **文献名称**: *"NHP2 Antibody Characterization in Telomerase Complex Assembly"*

**作者**: Smith A, et al.

**摘要**: 本研究利用兔源多克隆NHP2抗体，通过免疫共沉淀和Western blot技术，揭示了NHP2在人类端粒酶复合体组装中的关键作用，证实其与dyskerin蛋白的功能性互作。

2. **文献名称**: *"Monoclonal Anti-NHP2 Antibody as a Biomarker in Colorectal Cancer"*

**作者**: Zhang Y, et al.

**摘要**: 开发了一种高特异性小鼠单克隆NHP2抗体，用于免疫组化分析。结果显示，结直肠癌组织中NHP2蛋白显著高表达，提示其可能作为新型肿瘤诊断标志物。

3. **文献名称**: *"Autoantibodies Against NHP2 in Systemic Lupus Erythematosus"*

**作者**: Lee S, et al.

**摘要**: 通过ELISA检测系统性红斑狼疮(SLE)患者血清，发现抗NHP2自身抗体的存在与疾病活动度相关，为自身免疫病的分子机制研究提供了新方向。

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**备注**：以上文献为示例性质，实际研究中请通过PubMed或Google Scholar检索真实发表的论文，关键词建议为“NHP2 antibody”、“anti-NHP2”或“NHP2 autoantibody”。

       

背景信息

The NHP2 antibody is a crucial tool in studying the NHP2 protein, a component of the H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. NHP2. along with proteins like dyskerin, GAR1. and NOP10. plays a vital role in ribosomal RNA (rRNA) processing, telomerase RNA stabilization, and post-transcriptional modifications such as pseudouridylation. This complex is essential for ribosome biogenesis and telomere maintenance, linking NHP2 dysfunction to genetic disorders like dyskeratosis congenita (DKC), a condition characterized by bone marrow failure, skin abnormalities, and increased cancer risk.

Antibodies targeting NHP2 are widely used in molecular and cellular biology to investigate its expression, localization, and interactions within the H/ACA complex. They enable techniques like Western blotting, immunoprecipitation, and immunofluorescence, helping researchers dissect NHP2's role in ribosome assembly, telomere biology, and disease mechanisms. Studies using these antibodies have revealed how mutations in NHP2 disrupt rRNA processing and telomerase activity, contributing to DKC pathogenesis and cancer progression. Additionally, NHP2 antibodies are valuable in exploring connections between ribosomopathies, aging-related disorders, and telomere-associated diseases. Their application extends to diagnostic research, aiding in the identification of molecular biomarkers for early disease detection or therapeutic targeting.

       
NHP2抗体;NHP2;NHP2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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