RNF24抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and HL60 cell lysates, Primary antibody: P10004(RNF24 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10004(RNF24 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The RNF24 (Ring Finger Protein 24) antibody is a research tool designed to detect and study the RNF24 protein, a member of the E3 ubiquitin ligase family. RNF24 contains a conserved RING domain that facilitates its role in ubiquitination, a post-translational modification process critical for protein degradation, signal transduction, and cellular homeostasis. This protein is implicated in diverse biological processes, including endoplasmic reticulum (ER)-Golgi trafficking, vesicle transport, and stress response pathways. Dysregulation of RNF24 has been linked to pathologies such as cancer, neurodegenerative disorders, and cardiovascular diseases, highlighting its potential as a therapeutic target.

RNF24 antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate its expression, localization, and interactions in various tissues or cell lines. Researchers rely on these antibodies to explore RNF24's role in cellular mechanisms, such as modulating membrane protein stability or regulating autophagy. Specificity and validation of RNF24 antibodies are crucial, as cross-reactivity with homologous proteins (e.g., RNF19A/B) may occur due to structural similarities within the RING domain family. Recent studies also suggest RNF24's involvement in immune responses and viral infection pathways, expanding its relevance in both basic and translational research. Continued development of high-affinity RNF24 antibodies remains essential for unraveling its multifaceted functions in health and disease.