SNRPD1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09982(SNRPD1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09982(SNRPD1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

**Background of SNRPD1 Antibody**

SNRPD1 (Small Nuclear Ribonucleoprotein D1) is a core component of the spliceosome, a macromolecular complex essential for pre-mRNA splicing. It is part of the Sm protein family, which assembles into the Sm core of small nuclear ribonucleoproteins (snRNPs) that recognize splice sites on pre-mRNA. SNRPD1 plays a critical role in maintaining spliceosome stability and ensuring accurate splicing, a process vital for gene expression regulation.

Antibodies targeting SNRPD1 are widely used in research to study spliceosome assembly, RNA processing mechanisms, and their dysregulation in diseases. For example, abnormal splicing due to SNRPD1 dysfunction has been linked to cancers, neurodegenerative disorders, and autoimmune conditions. In systemic lupus erythematosus (SLE), autoantibodies against SNRPD1 are common diagnostic markers, highlighting its clinical relevance.

SNRPD1 antibodies are employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions. They are often validated for specificity using knockdown/knockout controls or mass spectrometry. Available as monoclonal or polyclonal variants from hosts like rabbit or mouse, these antibodies are crucial tools for exploring splicing mechanisms, cellular stress responses, and therapeutic targets in splicing-related pathologies. Researchers also use them to investigate SNRPD1's role in cell cycle regulation, apoptosis, and its potential as a biomarker in disease progression.