HIRIP3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09929(HIRIP3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09929(HIRIP3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The HIRIP3 (HIRA-interacting protein 3) antibody is a tool used to study the HIRIP3 protein, which plays a role in chromatin remodeling and transcriptional regulation. HIRIP3 interacts with HIRA, a histone chaperone complex responsible for depositing the histone variant H3.3 into chromatin, a process critical for DNA repair, gene expression, and developmental programming. This interaction positions HIRIP3 within pathways governing epigenetic modifications and genome stability.

The antibody is primarily utilized in research applications such as Western blotting, immunoprecipitation, and immunofluorescence to detect HIRIP3 expression, localization, and protein-protein interactions. Studies suggest HIRIP3 may contribute to cellular processes like meiosis, DNA damage response, and cell cycle regulation, though its precise molecular mechanisms remain under investigation. Dysregulation of HIRA-associated pathways has been linked to developmental disorders and cancer, implicating HIRIP3 as a potential biomarker or therapeutic target.

Researchers employ HIRIP3 antibodies to explore its functional roles in model organisms and human diseases, particularly in contexts involving chromatin dynamics and epigenetic inheritance. Validating antibody specificity is crucial, as cross-reactivity with related proteins could confound results. Overall, this reagent supports advancing knowledge in epigenetics, genome maintenance, and disease pathogenesis.