INPP1抗体—艾普蒂

The INPP1 (Inositol Polyphosphate-1-Phosphatase) antibody is a research tool designed to detect and study the INPP1 enzyme, which plays a critical role in regulating inositol phosphate metabolism. INPP1 catalyzes the hydrolysis of the 1-position phosphate from inositol 1.4.5-trisphosphate (Ins(1.4.5)P3) and inositol 1.3.4.5-tetrakisphosphate (Ins(1.3.4.5)P4), producing inositol 4.5-bisphosphate (Ins(4.5)P2) and inositol 3.4.5-trisphosphate (Ins(3.4.5)P3), respectively. This enzymatic activity influences cellular signaling pathways, including calcium mobilization, vesicle trafficking, and gene expression. INPP1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression levels, subcellular localization, and tissue distribution. Researchers employ these antibodies to explore INPP1's involvement in diseases such as cancer, neurological disorders, and metabolic syndromes, where inositol phosphate dysregulation has been implicated. Recent studies also highlight its potential role in modulating insulin signaling and apoptosis. Commercial INPP1 antibodies are typically raised against specific epitopes, often validated for cross-reactivity in human, mouse, or rat models. Proper controls, such as knockout validation or peptide blocking, are essential to ensure specificity in experimental applications.