PITPNB抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Rat brain tissue, Human cerebrum tissue, Human fetal brain tissue, Hela cell, Human breast cancer tissue, Jurkat cell lysates, Primary antibody: P09632(PITPNB Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09632(PITPNB Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The PITPNB (Phosphatidylinositol Transfer Protein Beta) antibody is a crucial tool for studying the function and regulation of the PITPNB protein, which plays a pivotal role in intracellular lipid transport and signaling. PITPNB belongs to the phosphatidylinositol transfer protein (PITP) family, facilitating the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membrane compartments. This activity is essential for maintaining lipid homeostasis, membrane trafficking, and signal transduction pathways, particularly those involving phosphoinositides. Dysregulation of PITPNB has been implicated in various physiological and pathological processes, including neurodevelopment, cancer progression, and metabolic disorders.

Researchers utilize PITPNB antibodies primarily in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization, and tissue distribution. These antibodies help elucidate PITPNB's interaction with signaling molecules, such as those in the PI3K/AKT pathway, and its role in cellular processes like vesicle formation and cytoskeletal organization. Commercially available PITPNB antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human or murine protein. Validation data, including knockout controls and species cross-reactivity, are critical for ensuring specificity. Ongoing studies continue to explore PITPNB's therapeutic potential, particularly in lipid metabolism-related diseases and neurological conditions, underscoring the antibody's importance in both basic and translational research.