SGCD抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P09615(SGCD Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09615(SGCD Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The sarcoglycan complex, part of the dystrophin-glycoprotein complex (DGC), plays a critical role in stabilizing muscle cell membranes during contraction. SGCD (δ-sarcoglycan) is a transmembrane protein encoded by the SGCD gene, predominantly expressed in skeletal and cardiac muscle. Mutations in SGCD are linked to limb-girdle muscular dystrophy type 2F (LGMD2F) and dilated cardiomyopathy, highlighting its importance in maintaining structural integrity and signaling in muscle tissues.

SGCD antibodies are autoantibodies targeting the δ-sarcoglycan protein. While rare, their presence is associated with autoimmune myopathies, particularly in overlap syndromes involving cardiac or skeletal muscle inflammation. These antibodies may disrupt the sarcoglycan complex, leading to membrane fragility, impaired force transmission, and muscle degeneration. Detection of SGCD antibodies (via immunoprecipitation or immunoassay) aids in diagnosing autoimmune-mediated muscle disorders, though they are less common than other myositis-specific autoantibodies.

Research on SGCD antibodies remains limited, but their identification contributes to understanding autoimmune mechanisms in neuromuscular diseases. Clinical relevance includes potential correlations with disease severity or cardiac involvement, warranting further investigation to refine diagnostic and therapeutic strategies.