DDX52抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09612(DDX52 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DDX52 antibody is designed to target the DEAD-box helicase 52 (DDX52) protein, a member of the DEAD-box RNA helicase family characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif. DDX52. also known as ROK1. plays a role in RNA metabolism, including ribosome biogenesis, RNA splicing, and translation regulation. It localizes primarily to the nucleolus, where it is implicated in rRNA processing and ribosome assembly, interacting with other ribosome-associated factors. Studies suggest DDX52 contributes to cell proliferation, stemness maintenance, and viral RNA sensing, linking it to pathways involving innate immunity and oncogenesis.

Antibodies against DDX52 are widely used in research to investigate its expression, localization, and molecular interactions. They are essential tools in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of DDX52 has been observed in cancers, including hepatocellular carcinoma and breast cancer, where its overexpression correlates with poor prognosis. Additionally, DDX52 interacts with viral RNAs, highlighting its role in host-pathogen interactions. Research utilizing DDX52 antibodies aims to elucidate its functional mechanisms in ribosome biogenesis, tumor progression, and immune responses. Despite its emerging significance, the precise molecular pathways and therapeutic potential of DDX52 remain under active exploration, underscoring the importance of specific antibodies in advancing this field.