DDX19A抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Jurkat cells using HMOX1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human Liver tissues using HMOX1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using HMOX1 mouse mAb with DAB staining.    

  
  

The DDX19A antibody is a tool used to study the DEAD-box helicase 19A (DDX19A), a member of the DEAD-box RNA helicase family involved in mRNA metabolism. DDX19A, encoded by the *DDX19A* gene, plays critical roles in mRNA export from the nucleus to the cytoplasm, translation regulation, and nonsense-mediated mRNA decay (NMD). It contains conserved DEAD (Asp-Glu-Ala-Asp) motifs essential for ATP-dependent RNA unwinding and remodeling. Dysregulation of DDX19A is linked to cancers, neurodegenerative diseases, and viral infections, as it interacts with viral RNA and host proteins during pathogenesis (e.g., SARS-CoV-2).

Antibodies targeting DDX19A enable researchers to investigate its expression, localization, and function in cellular contexts. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Commercial DDX19A antibodies are typically raised against specific epitopes (e.g., N-terminal or C-terminal regions) and validated for specificity using knockout cell lines or siRNA-mediated knockdown. Suppliers include Sigma-Aldrich, Abcam, and Cell Signaling Technology. Recent studies highlight DDX19A's role in stress granule formation and antiviral responses, underscoring its therapeutic potential. However, antibody validation remains crucial due to cross-reactivity risks with paralogs like DDX19B.