DAZ1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09591(DAZ1 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09591(DAZ1 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The DAZ1 antibody is a crucial tool in reproductive biology research, primarily targeting the Deleted in Azoospermia 1 (DAZ1) protein. DAZ1. a member of the DAZ gene family, is located on the Y chromosome and plays a critical role in spermatogenesis. It encodes an RNA-binding protein essential for germ cell development, particularly in the differentiation and maturation of sperm cells. Mutations or deletions in the DAZ1 gene are strongly associated with male infertility, specifically azoospermia (absence of sperm) or severe oligospermia (low sperm count).

DAZ1 antibodies are commonly utilized in immunohistochemistry, Western blotting, and immunofluorescence to detect DAZ1 protein expression in testicular tissues or germ cells. These antibodies help researchers study the spatial and temporal expression patterns of DAZ1 during spermatogenesis, shedding light on its functional mechanisms in fertility. Additionally, they serve as diagnostic tools in clinical studies to correlate DAZ1 protein levels with male reproductive disorders.

The development of DAZ1 antibodies has advanced understanding of Y chromosome-linked infertility and provided insights into potential therapeutic strategies. However, challenges persist due to the high homology among DAZ family proteins (DAZ1-DAZ4), requiring antibodies with high specificity to avoid cross-reactivity. Ongoing research aims to refine antibody specificity and explore DAZ1's interactions with other germ cell proteins, further unraveling its role in human reproduction.