POR抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P09582(POR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09582(POR Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

POR (Cytochrome P450 Oxidoreductase) antibodies are autoantibodies targeting the POR enzyme, a critical electron donor for cytochrome P450 (CYP) enzymes involved in steroidogenesis, drug metabolism, and bile acid synthesis. POR, located on the endoplasmic reticulum membrane, transfers electrons from NADPH to various CYP isoforms, including those essential for cortisol, estrogen, and vitamin D production.

The clinical relevance of POR antibodies primarily relates to autoimmune polyendocrine syndrome type 1 (APS-1), a rare autosomal recessive disorder caused by AIRE gene mutations. APS-1 is characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency. While 21-hydroxylase antibodies are common in APS-1-related adrenal failure, POR antibodies serve as additional biomarkers, particularly in seronegative cases. Their presence aids in diagnosing APS-1 and understanding autoimmune mechanisms targeting steroidogenic pathways.

Detection methods include immunoprecipitation or immunoassays using recombinant POR protein. Though their pathogenic role remains unclear, POR antibodies may interfere with electron transfer, potentially disrupting CYP enzyme activity and contributing to hormonal deficiencies. Research also links these antibodies to other autoimmune conditions, though their specificity for APS-1 remains stronger.

Overall, POR antibodies are valuable diagnostic tools in APS-1. highlighting the interplay between autoimmunity and metabolic dysfunction. Further studies are needed to elucidate their exact pathophysiological impact.