CYP2J2抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09581(CYP2J2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The CYP2J2 antibody is a specialized tool used to detect and study the cytochrome P450 2J2 (CYP2J2) enzyme, a member of the cytochrome P450 superfamily involved in xenobiotic metabolism and endogenous lipid signaling. CYP2J2 is primarily expressed in extrahepatic tissues, such as the heart, kidneys, and gastrointestinal tract, where it metabolizes arachidonic acid to produce epoxyeicosatrienoic acids (EETs). These metabolites play critical roles in cardiovascular homeostasis, including vasodilation, anti-inflammatory effects, and angiogenesis. Dysregulation of CYP2J2 has been linked to pathologies like hypertension, cancer, and diabetic complications, making it a target for therapeutic research.

The CYP2J2 antibody enables researchers to localize and quantify the enzyme in tissues or cell lines using techniques like Western blotting, immunohistochemistry, or immunofluorescence. Its specificity helps investigate CYP2J2 expression patterns under varying physiological or pathological conditions, such as tumor progression or drug interactions. Studies also utilize this antibody to explore CYP2J2's role in drug metabolism, particularly its involvement in metabolizing antihistamines and anticancer agents. As CYP2J2's EET products are increasingly recognized for their cardioprotective effects, the antibody supports research into developing enzyme-targeted therapies or biomarkers for cardiovascular and oncological diseases. Validation of antibody specificity through knockout controls or peptide blocking is essential to ensure reliable experimental outcomes.