CYP4F12抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09577(CYP4F12 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09577(CYP4F12 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The CYP4F12 antibody is a tool used to detect and study the cytochrome P450 family 4 subfamily F member 12 (CYP4F12) enzyme, which plays a role in metabolizing endogenous and exogenous compounds. CYP4F12 is part of the cytochrome P450 superfamily, known for oxidizing fatty acids, eicosanoids, and xenobiotics. This enzyme is primarily expressed in the liver, kidneys, and intestines, contributing to the metabolism of arachidonic acid derivatives, including leukotriene B4 and hydroxyeicosatetraenoic acids (HETEs), as well as certain drugs. Its genetic locus is on chromosome 19p13.12.

Research using CYP4F12 antibodies focuses on understanding its physiological roles, such as regulating inflammatory responses, lipid homeostasis, and drug clearance. These antibodies are essential in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, tissue distribution, and subcellular localization (e.g., endoplasmic reticulum or mitochondria). Dysregulation of CYP4F12 has been implicated in diseases like hypertension, cancer, and metabolic disorders, making its study clinically relevant. Monoclonal or polyclonal CYP4F12 antibodies are validated for specificity to ensure accurate detection, aiding investigations into enzyme function, genetic variants, and therapeutic targeting. Ongoing studies explore its interactions with lipid signaling pathways and potential as a biomarker or drug target.