CYP3A43抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09576(CYP3A43 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The CYP3A43 antibody is a research tool designed to detect and study the CYP3A43 enzyme, a member of the cytochrome P450 superfamily involved in drug metabolism and steroidogenesis. CYP3A43. encoded by the *CYP3A43* gene, is a less-characterized isoform compared to its well-studied counterparts (e.g., CYP3A4. CYP3A5). It is primarily expressed in the liver, testes, and adrenal glands, suggesting roles in hormone metabolism and xenobiotic processing. However, its precise substrates, catalytic activity, and physiological relevance remain unclear due to low expression levels and overlapping functions with other CYP3A enzymes.

CYP3A43 antibodies are typically polyclonal or monoclonal antibodies developed to identify the protein in immunological assays like Western blotting (WB), immunohistochemistry (IHC), or immunofluorescence (IF). These antibodies target specific epitopes within the CYP3A43 protein, aiding in the investigation of its tissue distribution, expression patterns under varying conditions (e.g., drug exposure, disease states), and interaction with regulatory proteins. Challenges in antibody development include ensuring specificity, as CYP3A isoforms share high sequence homology. Validation often involves knockout controls or siRNA-mediated silencing.

Current research using CYP3A43 antibodies focuses on elucidating its potential role in personalized medicine, pharmacogenomics, and interindividual variability in drug responses. Despite limited studies, its unique expression profile in reproductive and endocrine tissues hints at unexplored biological functions. Commercial availability of these antibodies supports ongoing efforts to clarify CYP3A43's contributions to metabolic pathways and disease mechanisms.