CRAT抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cell and Human heart tissue lysates, Primary antibody: P09568(CRAT Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09568(CRAT Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09568(CRAT Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

CRAT (carnitine O-acetyltransferase) antibodies are tools used to study the CRAT enzyme, a key player in cellular energy metabolism. CRAT facilitates the transfer of acyl groups between coenzyme A (CoA) and carnitine, enabling the transport of fatty acids into mitochondria for β-oxidation. This process is critical for maintaining energy homeostasis, particularly during fasting or high-fat metabolism. Dysregulation of CRAT activity has been implicated in metabolic disorders, including diabetes, obesity, and cardiovascular diseases, making it a target for therapeutic research.

CRAT antibodies are primarily employed in biomedical research to detect and quantify CRAT expression in tissues or cell lines. They enable investigations into CRAT's role in metabolic pathways, cellular stress responses, and disease mechanisms. For example, studies using these antibodies have linked reduced CRAT levels to mitochondrial dysfunction and insulin resistance. Commercially available CRAT antibodies are typically developed in rabbits or mice, targeting specific epitopes of human or mouse CRAT proteins. Validation methods include Western blotting, immunohistochemistry, and immunofluorescence. Recent research also explores CRAT's potential involvement in aging and neurodegenerative diseases, expanding the antibody's utility in diverse experimental models. Proper controls remain essential due to occasional cross-reactivity concerns in complex biological samples.