DMC1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09555(DMC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09555(DMC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

DMC1 (DNA Meiotic Recombinase 1) is a conserved eukaryotic protein essential for homologous recombination during meiosis, specifically facilitating the repair of double-strand breaks (DSBs) in DNA. As a meiosis-specific homolog of the bacterial RecA protein, DMC1 promotes strand exchange between homologous chromosomes, ensuring accurate chromosome pairing and crossover formation. This process is critical for genetic diversity and proper chromosome segregation in gametes.

Antibodies targeting DMC1 are widely used in research to study meiosis dynamics, particularly in germ cells. They enable the visualization and quantification of DMC1 foci—microscopic sites where recombination occurs—on meiotic chromosomes via techniques like immunofluorescence, Western blotting, or immunohistochemistry. Such studies have elucidated DMC1's role in fertility, its interaction with co-factors (e.g., RAD51. BRCA2), and its dysregulation in conditions like infertility or genomic instability.

Commercial DMC1 antibodies are typically raised against conserved epitopes, often validated in model organisms (e.g., mice, plants, yeast). Researchers rely on these tools to investigate meiotic defects, evolutionary conservation of recombination mechanisms, and potential links to reproductive disorders. Recent applications extend to CRISPR-edited cell lines or single-cell genomics, underscoring DMC1's enduring relevance in molecular and reproductive biology.