COG5抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09536(COG5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The COG5 antibody is a crucial tool for studying the Conserved Oligomeric Golgi (COG) complex, a multi-subunit protein assembly essential for maintaining Golgi apparatus structure and function. COG5 (Component of Oligomeric Golgi complex 5) is one of eight subunits (COG1-8) that form the COG complex, which regulates vesicle trafficking, glycosylation, and retrograde transport within the Golgi. Specifically, COG5 interacts with COG2. COG3. and COG4 to form the "lobe B" subcomplex, critical for tethering vesicles and ensuring proper localization of Golgi enzymes involved in protein and lipid modification.

Mutations in the COG5 gene are linked to congenital disorders of glycosylation (CDGs), such as COG5-CDG (CDG-II), characterized by developmental delays, neurological deficits, and abnormal protein glycosylation. Researchers use COG5 antibodies to investigate these pathologies, detect COG5 expression levels via techniques like Western blotting, immunofluorescence, or immunohistochemistry, and map its localization in cellular models. These antibodies also aid in studying COG5's role in disease mechanisms using knockout models or patient-derived cells.

Commercial COG5 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockdown/knockout controls. Their applications span basic research on Golgi dynamics, vesicular transport, and glycosylation pathways, as well as translational studies exploring diagnostic or therapeutic strategies for COG-related disorders.