COG2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09535(COG2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09535(COG2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The COG2 antibody is a research tool used to study the Conserved Oligomeric Golgi (COG) complex, a critical multi-subunit protein assembly involved in intracellular trafficking and Golgi apparatus maintenance. The COG complex, comprising eight subunits (COG1-8), regulates vesicle tethering, glycosylation, and retrograde transport within the Golgi. COG2 (component of oligomeric Golgi complex subunit 2), encoded by the *COG2* gene, is part of the COG1-4 subcomplex and plays a pivotal role in maintaining Golgi structure and function. Defects in COG2 disrupt glycosylation enzymes' localization, impairing protein and lipid glycosylation—a hallmark of congenital disorders of glycosylation (CDGs).

COG2-specific antibodies are essential for detecting COG2 protein expression, localization, and interactions in cellular models. Researchers use these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate COG2's role in Golgi dynamics and disease mechanisms. Mutations in *COG2* are linked to CDG type II (e.g., COG2-CDG), characterized by neurological and developmental abnormalities. Studying COG2 via its antibody helps elucidate molecular pathways in glycosylation disorders and potential therapeutic targets. Commercial COG2 antibodies are typically raised in rabbits or mice, validated for specificity, and widely used in cell biology and clinical research contexts.