CLUL1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raw264.7 cells, human fetal liver tissue, Primary antibody: P07082(ANXA4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P07082(ANXA4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CLUL1 (Crumbs homolog-like 1) antibody is a tool used to detect the CLUL1 protein, a member of the Crumbs family involved in maintaining cell polarity and epithelial integrity. CLUL1 shares structural homology with the Crumbs proteins, which are critical for apical-basal polarity and tight junction formation in epithelial cells. While less studied than its homolog CRB3. CLUL1 is implicated in cell adhesion, tissue morphogenesis, and photoreceptor maintenance in the retina.

CLUL1 antibodies are typically developed in immunized hosts (e.g., rabbits or mice) using peptide antigens derived from conserved regions of the CLUL1 protein. These antibodies enable researchers to study CLUL1's expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of CLUL1 has been loosely associated with retinal degeneration and epithelial disorders, though its precise pathological roles remain under investigation.

Recent studies highlight CLUL1's potential interaction with polarity complexes (e.g., PAR/aPKC) and its role in stabilizing cell-cell junctions. However, challenges persist in distinguishing CLUL1-specific signals from cross-reactivity with other Crumbs family members, necessitating rigorous validation of antibody specificity. Available CLUL1 antibodies vary in clonality (monoclonal/polyclonal) and host species, catering to diverse experimental needs. Ongoing research aims to clarify CLUL1's contributions to development and disease, leveraging these antibodies as key reagents.