CLK4抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09523(CLK4 Antibody) at dilution 1/170. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09523(CLK4 Antibody) at dilution 1/170. (Original magnification: ×200)    

  
  

CLK4 (CDC-like kinase 4) is a serine/threonine kinase belonging to the CLK family, which includes CLK1-4. These kinases regulate RNA splicing by phosphorylating serine/arginine-rich (SR) proteins, influencing their subcellular localization and activity. CLK4. like other CLK members, contains a conserved kinase domain and is implicated in modulating pre-mRNA processing, cellular signaling, and stress responses. Dysregulation of CLK kinases has been linked to diseases such as cancer, neurodegenerative disorders, and viral infections.

CLK4-specific antibodies are essential tools for studying its expression, localization, and function. They enable detection of CLK4 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using CLK4 antibodies has revealed its tissue-specific expression patterns and potential roles in developmental processes and disease pathogenesis. For instance, CLK4 overexpression has been observed in certain cancers, suggesting a therapeutic target. However, CLK4's functional overlap with other CLK family members complicates its individual characterization, necessitating highly specific antibodies. Commercial CLK4 antibodies are typically validated for cross-reactivity and affinity, though variability between batches or clones may require careful optimization. Ongoing studies aim to clarify CLK4's unique contributions to cellular pathways and its interplay with splicing regulators, highlighting its relevance in both basic research and drug discovery.