CLASP1抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse fetal brain tissue lysate, Primary antibody: P09517(CLASP1 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09517(CLASP1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

CLASP1 (cytoplasmic linker-associated protein 1) is a microtubule-associated protein critical for regulating microtubule dynamics, cell polarity, and intracellular transport. It belongs to the CLASP family, which interacts with the cytoskeleton to stabilize microtubules at specific subcellular regions, such as the cell cortex or Golgi apparatus. CLASP1’s activity is tightly regulated by signaling pathways, including the Wnt/GSK3β pathway, enabling it to coordinate microtubule behavior with cellular signaling cues. Its roles span mitosis, cell migration, and neuronal development, where it ensures proper spindle orientation, directional movement, and axon guidance.

CLASP1 antibodies are essential tools for studying these processes. They are widely used in techniques like immunofluorescence, Western blotting, and immunoprecipitation to localize CLASP1. assess expression levels, or identify binding partners. Researchers also utilize these antibodies to investigate CLASP1’s involvement in diseases; dysregulation of CLASP1 has been linked to cancer metastasis (via enhanced cell invasiveness) and neurological disorders (due to impaired neuronal transport). Specific antibodies may target distinct isoforms or post-translational modifications, aiding in functional studies of CLASP1 variants. Validation of CLASP1 antibodies often includes knockout controls or siRNA knockdown to confirm specificity. Overall, CLASP1 antibodies provide critical insights into cytoskeletal regulation and its pathological disruptions.