TBCB抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human cerebrum tissue lysate, Primary antibody: P09515(TBCB Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09515(TBCB Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of TBCB Antibody**

Tubulin folding cofactor B (TBCB) is a chaperone protein critical for the proper folding and assembly of β-tubulin into functional α/β-tubulin heterodimers, the building blocks of microtubules. Microtubules are dynamic cytoskeletal structures essential for cell division, morphology, and intracellular transport. TBCB, along with other cofactors (e.g., TBCE), participates in a multistep pathway to ensure β-tubulin acquires its native conformation, preventing aggregation or misfolding.

TBCB antibodies are tools designed to detect and study TBCB expression, localization, and function in biological systems. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate TBCB's role in microtubule dynamics and associated pathologies. Dysregulation of TBCB has been implicated in neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease, as well as cancer, where altered microtubule stability affects cell proliferation and migration.

Research using TBCB antibodies has also highlighted its interaction with tubulin isotypes and cofactors, shedding light on mechanisms underlying tubulinopathies—diseases caused by defective tubulin folding or assembly. Additionally, studies in model organisms reveal that TBCB depletion disrupts microtubule networks, leading to cellular defects. These insights underscore TBCB's importance in maintaining cytoskeletal integrity and its potential as a therapeutic target or biomarker in microtubule-related diseases.