CISD1抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Mouse skeletal muscle tissue, Human heart tissue, Mouse brain tissue, 293T cell, PC-3 cell, HEPG2 cell, Mouse liver tissue lysates, Primary antibody: P09513(CISD1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09513(CISD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CISD1 antibody targets the CISD1 protein (also known as ZCD1 or Miner1), a key player in mitochondrial function and cellular homeostasis. CISD1 is a member of the NEET protein family, characterized by its CDGSH iron-sulfur domain, and localizes to the outer mitochondrial membrane. It regulates iron-sulfur cluster transfer, redox signaling, and mitochondrial dynamics, influencing processes like autophagy, oxidative stress response, and energy metabolism. CISD1 dysfunction is linked to Wolfram syndrome type 2 (WFS2), a rare autosomal recessive disorder causing diabetes, neurodegeneration, and early mortality. Studies in mice show that CISD1 loss accelerates aging and disrupts mitochondrial integrity.

CISD1 antibodies are essential tools for investigating these mechanisms. They enable detection and quantification of CISD1 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to study CISD1's role in disease models, including metabolic disorders, cancer (where it may act as an oncogenic marker), and neurodegenerative conditions. Commercial CISD1 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knock-out controls to ensure specificity. Ongoing research explores CISD1 as a therapeutic target, emphasizing its potential in modulating mitochondrial health and disease progression.